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Breast cancer

Phosphatidylinositol-5-phosphate 4-kinase type IIa (PIP4K2A); PIP4K2B

Mouse and cell culture studies suggest inhibiting PIP4K2A and PIP4K2B could help treat p53- breast cancer. In human breast cancer samples, deletion of TP53, which encodes p53, increased PIP4K2B levels compared with no alteration. In cultured TP53-deficient breast cancer cells and mouse xenografts, knockdown of both PIP4K2A and PIP4K2B decreased cancer cell proliferation and tumor formation compared with no alteration. In Tp53-deficient mice, homozygous deletion of Pip4k2a and heterozygous deletion of Pip4k2b decreased tumor formation. Next steps could include studies to understand the relationship between PIP4K2A and PIP4K2B and glucose metabolism in tumors.

SciBX 6(48); doi:10.1038/scibx.2013.1377
Published online Dec. 19, 2013

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Emerling, B.M. et al. Cell;
published online Nov. 7, 2013;
Contact: Lewis C. Cantley, Harvard Medical School, Boston, Mass.