This week in therapeutics

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Target/marker/pathway

Summary

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Neurology

Stroke

Thyroid hormone receptor-a

Studies in human tissue and rabbits suggest thyroid hormone receptor-a agonists could protect against neurodevelopmental damage caused by intraventricular hemorrhage in preterm infants. In postmortem samples from preterm infants, brain tissue from infants with intraventricular hemorrhage had higher thyroid hormone receptor-a levels than tissue from nonhemorrhaged controls. In a rabbit pup model of intraventricular hemorrhage, thyroid hormone improved myelination and neurological function over vehicle. Next steps could include identifying and testing thyroid hormone receptor-a agonists in preclinical models of prematurity-associated neurological damage.

SciBX 6(47); doi:10.1038/scibx.2013.1358
Published online Dec. 12, 2013

Patent and licensing status undisclosed

Vose, L.R. et al. J. Neurosci.; published online Oct. 30, 2013;
doi:10.1523/JNEUROSCI.2713-13.2013
Contact: Praveen Ballabh, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, N.Y.
e-mail:
pballabh@msn.com