This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Staphylococcus

ClpP

Cell culture and mouse studies suggest combining the antibiotic acyldepsipeptide 4 (ADEP4) with rifampicin could help eradicate biofilms. In stationary methicillin-resistant S. aureus (MRSA), ADEP4 activated the clpP protease and led to extensive protein degradation. In culture and a mouse model of chronic infection, ADEP4 plus rifampicin eradicated MRSA biofilms, whereas rifampicin alone did not. Next steps include additional tests on ADEP4 plus other antibiotics for toxicity and efficacy.
Rifampicin is a generic antibiotic (see ClpPing persistence, page 4).

SciBX 6(47); doi:10.1038/scibx.2013.1357
Published online Dec. 12, 2013

Patents filed covering sterilizing use of ADEP4 and related compounds in combination with other antibiotics and covering ADEP4 analogs; licensed to Arietis Corp.; available for partnering

Conlon, B.P. et al. Nature; published online Nov. 13, 2013;
doi:10.1038/nature12790
Contact: Kim Lewis, Northeastern University, Boston, Mass.
e-mail:
k.lewis@neu.edu