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Endocrine/metabolic disease


Nicotinic acid adenine dinucleotide phosphate (NAADP)

Cell culture and mouse studies suggest NAADP analogs could help treat type 2 diabetes. In pancreatic b cells and adipocytes cultured in high glucose concentrations, NAADP increased intracellular insulin production and glucose uptake compared with no treatment. In a mouse model of obesity and type 2 diabetes, NAADP increased insulin production and glucose clearance compared with no treatment. Next steps include identifying stable NAADP analogs and testing them in additional diabetes models.

SciBX 6(47); doi:10.1038/scibx.2013.1351
Published online Dec. 12, 2013

Patent applications filed; available for licensing

Park, K.-H. et al. J. Biol. Chem.; published online Oct. 28, 2013;
Contact: Uh-Hyun Kim, Chonbuk National University Medical School, Jeonju, South Korea