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Inflammation; thrombosis

Factor Xa; factor XIa; kallikrein

In vitro and rodent studies suggest desmolaris, a protein from vampire bat saliva, could help treat inflammation and thrombosis. A series of in vitro assays identified desmolaris in vampire bat saliva as a slow, tight, noncompetitive inhibitor of factor Xa and XIa and a partial inhibitor of kallikrein. In mouse models of thrombosis and thromboembolism, desmolaris decreased arterial occlusion and increased survival compared with saline. In mice, injection of desmolaris-treated factor Xa decreased paw inflammation compared with injection of saline-treated factor Xa. Next steps include establishing a partnership for further preclinical and clinical development of desmolaris.

SciBX 6(46); doi:10.1038/scibx.2013.1328
Published online Dec. 5, 2013

Patent application filed; available for licensing from the NIH
Contact: Charlene Sydnor, National Institutes of Health (NIH), Bethesda, Md.

Ma, D. et al. Blood; published online Oct. 24, 2013;
Contact: Ivo M.B. Francischetti, National Institutes of Health (NIH), Bethesda, Md.