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Musculoskeletal disease

Musculoskeletal disease

TNF-like weak inducer of apoptosis (TWEAK)

In vitro and mouse studies suggest inhibiting TWEAK could promote muscle regeneration after injury. In Tweak-/- mice, the number of self-renewing satellite cells in muscle after injury was higher than that in wild-type controls. In primary satellite cells from the mice, Tweak decreased the number of self-renewing satellite cells compared with no treatment. Next steps could include testing the effects of TWEAK inhibition on muscle regeneration.
Biogen Idec Inc. has BIIB023, a mAb against TWEAK, in Phase II trials to treat lupus nephritis.

SciBX 6(46); doi:10.1038/scibx.2013.1326
Published online Dec. 5, 2013

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Ogura, Y. et al. J. Biol. Chem.; published online Oct. 22, 2013;
Contact: Ashok Kumar, University of Louisville School of Medicine, Louisville, Ky.