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Infectious disease

Chagas disease; leishmaniasis


In vitro and mouse studies have identified a class of tubulin inhibitors that could help treat parasitic infections. Chemical synthesis and in vitro testing of sulfonamide analogs identified several tubulin inhibitors that killed Trypanosoma cruzi and four Leishmania species at low nanomolar IC50 values. In a mouse model of Chagas disease, one lead compound decreased blood levels of T. cruzi by 72% and increased survival compared with no treatment. In a mouse model of leishmaniasis, another lead compound decreased the burden of L. infantum in the spleen and liver by 96% compared with no treatment. Next steps could include lead optimization of the two compounds.

SciBX 6(46); doi:10.1038/scibx.2013.1322
Published online Dec. 5, 2013

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Galiana-Roselló, C. et al. J. Med. Chem.; published online
Oct. 23, 2013;
Contact: M. Eugenia González-Rosende, Cardinal Herrera University, Valencia, Spain