This week in therapeutics




Licensing status

Publication and contact information

Infectious disease


Plasmodium falciparum phosphoethanolamine N-methyltransferase (PfPMT)

Cell culture studies suggest inhibiting PfPMT could help prevent P. falciparum infection and transmission. In P. falciparum cultures, knockout of PfPMT prevented the generation of mature gametocytes, a critical step in malaria transmission. In red blood cell-cultured P. falciparum, a PfPMT inhibitor increased death compared with no treatment and limited growth of gametocytes depending on their developmental stage. Next steps include synthesizing analogs of the inhibitor and testing them in mouse models of malaria.

SciBX 6(45); doi:10.1038/scibx.2013.1295
Published online Nov. 21, 2013

Unpatented; available for licensing from the Yale School of Medicine Office of Cooperative Research

Bobenchik, A.M. et al. Proc. Natl. Acad. Sci. USA; published online Oct. 21, 2013;
Contact: Choukri Ben Mamoun, Yale School of Medicine, New Haven, Conn.