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Dental disease


Chemokine CC motif ligand 22 (CCL22)

Animal studies suggest CCL22-loaded microparticles could help treat periodontitis. In mouse models of the indication, gingival injection of polymer microparticles loaded with mouse Ccl22 recruited Treg cells to the injection site and decreased gingival levels of proinflammatory cytokines, levels of matrix metalloproteinases and loss of alveolar bone compared with injection of empty microparticles. In dog models of periodontitis, topical application of CCL22-loaded microparticles to subgingival pockets decreased pocket depth, gingival inflammation and alveolar bone loss compared with empty microparticles. Ongoing work includes preclinical safety testing of the CCL22-loaded microparticles (see Getting to the root of periodontitis, page 6).

SciBX 6(45); doi:10.1038/scibx.2013.1290
Published online Nov. 21, 2013

Patented by the University of Pittsburgh; available for licensing or partnering

Glowacki, A.J. et al. Proc. Natl. Acad. Sci. USA; published online
Oct. 28, 2013;
Contact: Steven R. Little, University of Pittsburgh, Pittsburgh, Pa.