Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Inflammation

Allergy

IgE

In vitro and mouse studies suggest inhibiting weak affinity allergen-IgE interactions could help prevent allergies. In a rat cell culture model, tetravalent allergens were shown to bind IgE and induce mast cell degranulation, an initial step in triggering allergic reactions. A bivalent inhibitor that targets both the antigen- and nucleotide-binding sites on IgE inhibited mast cell degranulation induced by a tetravalent allergen, whereas inhibitors that only target one of the two sites did not. In a mouse model of allergy, the bivalent inhibitor decreased tetravalent allergen-induced ear swelling compared with no treatment. Next steps could include testing the bivalent inhibitor in additional models of allergy.

SciBX 6(43); doi:10.1038/scibx.2013.1231
Published online Nov. 7, 2013

Patent and licensing status unavailable

Handlogten, M.W. et al. Nat. Chem. Biol.; published online Oct. 6, 2013;
doi:10.1038/nchembio.1358
Contact: Basar Bilgicer, University of Notre Dame, Notre Dame, Ind.
e-mail:

bbilgicer@nd.edu