Indication

Target/marker/pathway

Summary

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Publication and contact information

Cancer

Cancer

Heparan sulfate glycosaminoglycan (HSGAG)

Cell culture studies suggest inhibiting HSGAG-dependent exosome uptake by noncancerous cells could help prevent exosome-mediated tumor development. Exosome-mediated trafficking of signaling molecules and other tumorigenic factors has recently been linked to cancer proliferation. In cell culture, fluorescently labeled exosomes derived from a glioblastoma multiforme (GBM) cell line bound to HSGAGs. In HSGAG-deficient cell lines or cells treated with the HSGAG antagonist heparin, exosome uptake was lower than that in wild-type cells or cells given no treatment. Next steps could include screening for small molecule inhibitors of exosome binding.

SciBX 6(43); doi:10.1038/scibx.2013.1218
Published online Nov. 7, 2013

Patent and licensing status unavailable

Christianson, H.C. et al. Proc. Natl. Acad. Sci. USA; published online
Oct. 7, 2013;
doi:10.1073/pnas.1304266110
Contact: Mattias Belting, Lund University, Lund, Sweden
e-mail:

mattias.belting@med.lu.se