Thursday, October 31, 2013
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Ribonucleotide reductase M2 (RRM2;
culture and mouse studies identified RRM2 inhibitors that could help treat
drug-resistant cancers. In cancer cell lines resistant to the ribonucleotide
reductase inhibitors hydroxyurea and Gemzar
the lead RRM2 inhibitor decreased proliferation compared with hydroxyurea or
gemcitabine alone. In mouse xenograft models of human ovarian cancer or
leukemia, the inhibitor caused tumor regression. Next steps could include
testing the inhibitor in additional cancer models.
Lilly and Co. markets Gemzar to treat breast, ovarian,
pancreatic and prostate cancers.
markets the ribonucleotide reductase inhibitor Clolar
to treat acute lymphoblastic leukemia (ALL).
Pharmaceuticals Inc.'s CALAA-01,
a small interfering RNA duplex targeting the M2 subunit of RRM2 and delivered
via the RNAi/oligonucleotide
nanoparticle delivery (RONDEL)
system, is in Phase I testing to treat solid tumors.
Published online Oct. 31, 2013
Patent and licensing status
Zhou, B. et al. Cancer
published online Sept. 26, 2013;
Contact: Yun Yen, City of Hope, Duarte, Calif.
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