Thursday, October 31, 2013
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Colony-stimulating factor 1 receptor (CSF1R;
studies suggest the brain-penetrant CSF1R inhibitor BLZ945
could be used to treat glioblastoma multiforme (GBM). In a mouse model of platelet
derived growth factor B (PDGFB;
proneural GBM, BLZ945 inhibited tumor-associated macrophages and blocked
glioma growth, and it increased survival compared with vehicle. In mice with
proneural GBM xenografts, BLZ945 decreased tumor growth, tumor invasion and
expression of activated macrophage markers associated with tumor-promoting
functions compared with vehicle. Next steps could include using CSF1R
inhibitors in combination with glioma cell-directed therapies.
Institutes for BioMedical Research synthesized
BLZ945 and collaborated on this study. The development status of the compound
BioPharma Inc. has the small molecule CSF1R inhibitor ARRY-382
in Phase I testing to treat cancer.
Inc. has the humanized mAb AMG 820
in Phase I trials to treat cancer.
Lilly and Co. has the humanized mAb IMC-CS4
in Phase I testing to treat solid tumors.
has the humanized mAb RG7155
in Phase I trials to treat solid tumors.
Published online Oct. 31, 2013
Patent application filed by
AG and the Memorial
Sloan-Kettering Cancer Center; licensing status undisclosed
Pyonteck, S.M. et al.
Nat. Med.; published online Sept. 22, 2013;
Contact: Johanna A. Joyce, Memorial Sloan-Kettering Cancer
New York, N.Y.
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