This week in therapeutics

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Infectious disease

Tuberculosis

Mycobacterium tuberculosis L-asparagine permease AnsP1 (AnsP1)

In vitro and mouse studies suggest inhibiting AnsP1 could help treat tuberculosis. In M. tuberculosis, deletion of AnsP1, a transporter that mediates nitrogen assimilation from aspartate, prevented bacterial growth when aspartate was the only nitrogen source. In mice, an M. tuberculosis strain lacking AnsP1 was less infectious than a wild-type strain. Next steps could include identifying compounds that inhibit the AnsP1 transporter.

SciBX 6(41); doi:10.1038/scibx.2013.1164
Published online Oct. 24, 2013

Unpatented; licensing status not applicable

Gouzy, A. et al. Nat. Chem. Biol.; published online Sept. 29, 2013;
doi:10.1038/nchembio.1355
Contact: Olivier Neyrolles, Institute of Pharmacology and Structural Biology, Toulouse, France
e-mail:
olivier.neyrolles@ipbs.fr