This week in therapeutics




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Publication and contact information

Infectious disease


Activation-induced cytidine deaminase (AICDA; AID);
IL-1b; tumor necrosis factor-a (TNF-a)

In vitro studies suggest activating AID could help prevent HBV infection. In a cytokine screen in cultured hepatocytes, IL-1b and TNF-a decreased susceptibility to HBV infection and increased expression of AID compared with no treatment. In the hepatocytes, lentiviral vector-mediated expression of AID decreased HBV infection compared with an empty vector. Next steps include confirming the effect of IL-1b and TNF-a in an animal model and identifying therapeutics that activate the pathway.

SciBX 6(41); doi:10.1038/scibx.2013.1163
Published online Oct. 24, 2013

Findings unpatented; unavailable for licensing

Watashi, K. et al. J. Biol. Chem.; published online Sept. 11, 2013;
Contact: Hideki Aizaki, National Institute of Infectious Diseases, Tokyo, Japan

Contact: Koichi Watashi, same affiliation as above