This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Dermatology

Wounds

IL-17A

Mouse studies suggest IL-17A could help treat dermal wounds and that wound healing in patients receiving IL-17 inhibitors should be monitored. In wounded mice, Il-17a knockout or treatment with anti-Il-17a antibodies decreased wound healing compared with no knockout or treatment with an IgG control. In wounded mice, addition of dendritic epidermal T cells that express Il-17a to the wound bed increased healing compared with addition of Il-17a knockout cells. Next steps include testing whether IL-17A is involved in the human wound-healing response.

SciBX 6(41); doi:10.1038/scibx.2013.1161
Published online Oct. 24, 2013

Patent and licensing status undisclosed

Macleod, A.S. et al. J. Clin. Invest.; published online Sept. 24, 2013;
doi:10.1172/JCI70064
Contact: Wendy L. Havran, The Scripps Research Institute, La Jolla, Calif.
e-mail:
havran@scripps.edu