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Autoimmune disease

Rheumatoid arthritis (RA)

Porphyromonas gingivalis peptidyl arginine deiminase (PgPADI; PgPAD)

Mouse studies suggest inhibiting PgPAD could help treat RA. In mice, inoculation with wild-type P. gingivalis increased levels of protein citrullination and production of antibodies against citrullinated proteins compared with PAD-deficient P. gingivalis. In a collagen-induced arthritis mouse model, infection with wild-type P. gingivalis increased the proportion of mice that developed the condition and the severity of arthritic symptoms compared with infection with PAD-deficient P. gingivalis. Next steps include testing inhibitors of human PAD (PADI) and PgPAD in preclinical models of RA.

SciBX 6(41); doi:10.1038/scibx.2013.1154
Published online Oct. 24, 2013

Patent and licensing information available from 4SC AG and the Gums and Joints Consortium

Maresz, K.J. et al. PLoS Pathog.; published online Sept. 12, 2013;
Contact: Piotr Mydel, University of Bergen, Bergen, Norway