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Parkinson's disease (PD)

Dopamine D5 receptor

Studies in rodents suggest inhibiting dopamine D5 receptor in the subthalamic nucleus (STN) could help treat PD. In brain slices from normal rats, a dopamine D5 receptor inverse agonist decreased constitutive activity of dopamine D5 receptor compared with buffer. In brain slices from normal and dopamine-depleted rats, the inverse agonist decreased burst firing in the STN compared with buffer. In motor-impaired, dopamine-depleted rats, intrasubthalamic injection of the inverse agonist increased locomotor activity and normalized cellular metabolic activity compared with saline injection. Next steps could include designing dopamine D5 receptor-specific antagonists and testing in preclinical models of PD.

SciBX 6(40); doi:10.1038/scibx.2013.1136
Published online Oct. 17, 2013

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Chetrit, J. et al. J. Neurosci.; published online Sept. 11, 2013;
Contact: Abdelhamid Benazzouz, University of Bordeaux Segalen, Bordeaux, France