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Hepatic disease

Drug-induced liver injury (DILI)

Ceramide synthase 2 (CERS2)

Mouse studies suggest inhibiting CERS2 could help treat and prevent drug-induced liver injury. In mice, Cers2 knockout protected against acetaminophen overdose-induced liver damage. The Cers2 knockout mice also were protected from the hepatotoxic effects of d-galactosamine, carbon tetrachloride and thioacetamide, whereas wild-type mice were not. Next steps could include developing and evaluating pharmacological inhibitors of CERS2 in animal models of drug-induced liver injury.

SciBX 6(40); doi:10.1038/scibx.2013.1131
Published online Oct. 17, 2013

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Park, W.-J. et al. J. Biol. Chem.; published online Sept. 9, 2013;
Contact: Anthony H. Futerman, Weizmann Institute of Science,
Rehovot, Israel