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Integrin-linked kinase (ILK); parvin-b (PARVB)

Mouse and cell culture studies suggest inhibiting ILK and PARVB signaling could help prevent tumor metastasis. In murine mammary carcinoma cell lines, small hairpin RNA knockdown of Ilk or Parvb decreased filopodium-like protrusion (FLP) formation and metastatic potential compared with no knockdown. In mice injected with metastatic mammary carcinoma cells, shRNA knockdown of Parvb or Ilk decreased the number of metastatic lesions in the lung compared with no knockdown. Next steps include using mouse models to determine whether and how blockade of this signaling pathway impedes metastasis and whether the blockade of this pathway has any therapeutic value.

SciBX 6(39); doi:10.1038/scibx.2013.1089
Published online Oct. 10, 2013

Unpatented; licensing status not applicable

Shibue, T. et al. Cancer Cell; published online Sept. 12, 2013;
Contact: Robert A. Weinberg, Whitehead Institute for Biomedical Research, Cambridge, Mass.