Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Renal disease

Glomerulonephritis

Chemokine CX3C motif receptor 1 (CX3CR1)

Mouse studies suggest inhibiting CX3CR1 could help treat glomerulonephritis. In a mouse model of crescentic glomerulonephritis, Cx3cr1 knockout decreased both the number of inflammation-mediating dendritic cells in kidneys and disease severity compared with wild-type Cx3cr1 expression. Next steps could include developing and evaluating CX3CR1 inhibitors.

SciBX 6(38); doi:10.1038/scibx.2013.1071
Published online Oct. 3, 2013

Patent and licensing status unavailable

Hochheiser, K. et al. J. Clin. Invest.; published online Sept. 3, 2013;
doi:10.1172/JCI70143
Contact: Christian Kurts, Institute of Molecular Medicine and Experimental Immunology, Bonn, Germany
e-mail:
ckurts@web.de

Contact: Katharina Hochheiser, University of Bonn, Bonn, Germany
e-mail:
khochhei@uni-bonn.de