Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Alzheimer's disease (AD)

Calcium release-activated calcium channel (CRAC)

Cell culture studies suggest agonizing CRAC could be useful for treating AD. In human embryonic kidney (HEK) cells overexpressing amyloid precursor protein (APP), overexpression of a constitutively active form of CRAC decreased b-amyloid (Ab) secretion compared with wild-type CRAC expression. Next steps include identifying compounds that activate CRAC-mediated calcium entry and testing them in cultured neurons and mouse models of AD.

SciBX 6(38); doi:10.1038/scibx.2013.1067
Published online Oct. 3, 2013

Unpatented; licensing status not applicable

Zeiger, W. et al. J. Biol. Chem.; published online July 31, 2013;
doi:10.1074/jbc.M113.473355
Contact: Gopal Thinakaran, The University of Chicago, Chicago, Ill.
e-mail:
gopal@uchicago.edu

Contact: Mitchel L. Villereal, same affiliation as above
e-mail:
mvillere@bsd.uchicago.edu