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Alzheimer's disease (AD)

b-Amyloid (Ab)

In vitro studies identified synthetic peptides derived from Russell's viper venom that could help treat AD. Treatment of aggregated Ab with synthetic peptides derived from a venom protein destabilized the aggregates and caused disassembly into nontoxic monomers. In a human neuroblastoma cell line treated with Ab aggregates, pretreatment with the synthetic peptides decreased cell death and cytotoxicity of the aggregates compared with pretreatment using nonspecific control peptides. Next steps include testing the peptides in animal models of AD and for human blood brain barrier penetration.

SciBX 6(38); doi:10.1038/scibx.2013.1066
Published online Oct. 3, 2013

Findings unpatented; unavailable for licensing

Bhattacharjee, P. & Bhattacharyya, D.
J. Biol. Chem.; published online
Aug. 28, 2013;
Contact: Debasish Bhattacharyya, CSIR-Indian Institute of Chemical Biology, Kolkata, India

Contact: Payel Bhattacharjee, same affiliation as above