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Infectious disease

Viral infection

IL-6 signal transducer (IL-6ST; gp130; CD130); IL-27; IL-27 receptor-a (IL27RA)

Mouse studies suggest increasing IL-27 signaling through gp130 and IL27RA could help control chronic viral infections. In mice infected with lymphocytic choriomeningitis virus (LCMV), gp130 knockout in CD4+ T cells decreased CD4+ and CD8+ T cell immune responses compared with no knockout and led to chronic infection. In the same model, knockout of IL27RA also led to chronic infection. Next steps include testing whether inducing gp130 signaling on virus-specific T cells enhances chronic virus clearance.

SciBX 6(38); doi:10.1038/scibx.2013.1065
Published online Oct. 3, 2013

Unpatented; available for licensing

Harker, J.A. et al. Immunity; published online Aug. 29, 2013;
Contact: Elina I. Zuniga, University of California, San Diego, Calif.