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Breast cancer

Thioesterase superfamily member 4 (THEM4; CTMP)

Studies in cell culture, mice and human tissue samples suggest inhibiting CTMP could help treat breast cancer. In a breast cancer cell line, small hairpin RNA knockdown of CTMP decreased proliferation compared with no knockdown. In a mouse xenograft model of breast cancer, CTMP overexpression increased tumorigenesis compared with wild-type CTMP expression. In human tissue samples, CTMP expression was higher in breast tumor cells than in normal cells, and expression of CTMP correlated with poor patient prognosis. Next steps could include designing and testing CTMP inhibitors in animal models.

SciBX 6(38); doi:10.1038/scibx.2013.1056
Published online Oct. 3, 2013

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Liu, Y.-P. et al. Cancer Res.; published online Aug. 13, 2013;
Contact: Pei-Jung Lu, National Cheng Kung University, Tainan, Taiwan