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Huntington's disease

Glutathione peroxidase 1 (GPX1); glutathione peroxidase 3 plasma (GPX3)

Yeast and fly studies suggest glutathione peroxidase mimics could be used to treat Huntington's disease. In a yeast-based, genome-wide screen, gpx1 and gpx3 were identified as suppressors of mutant huntingtin (htt) protein toxicity. In a Drosophila model of Huntington's disease, a glutathione peroxidase mimic decreased degeneration of photoreceptor neurons compared with no treatment and restored normal locomotor activity. Next steps include testing glutathione peroxidase mimics in mouse models of Huntington's disease.

SciBX 6(37); doi:10.1038/scibx.2013.1037
Published online Sept. 26, 2013

Unpatented; licensing status not applicable

Mason, R.P. et al. Nat. Genet.; published online Aug. 25, 2013;
Contact: Flaviano Giorgini, University of Leicester, Leicester, U.K.