This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Depression

Calcium calmodulin-dependent protein kinase IIb (CAMK2B)

Rodent studies suggest decreasing CAMK2B activity in the lateral habenula region of the brain could help treat depression. In three rat models of depression, Camk2b levels were higher in this region than those in healthy controls. In a rat model of depression, both the generic antidepressant imipramine and Camk2b-targeting RNAi decreased Camk2b levels and depression symptoms compared with vehicle or control RNAi. Next steps include developing a method for targeted drug delivery to the lateral habenula.

SciBX 6(37); doi:10.1038/scibx.2013.1034
Published online Sept. 26, 2013

Patent application filed; licensing status undisclosed

Li, K. et al. Science;
published online Aug. 30, 2013;
doi:10.1126/science.1240729
Contact: Hailan Hu, Chinese Academy of Sciences, Shanghai, China
e-mail:
hailan@ion.ac.cn