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Cognitive dysfunction

Retinoblastoma binding protein 4 (RBBP4; RBAP48)

Studies in patient samples and mice suggest increasing RBAP48 levels could help treat age-associated memory impairment. Gene expression analysis in postmortem brain tissue samples showed that RBAP48 levels decreased with age. In young transgenic mice, inhibition of Rbap48 signaling in the dentate gyrus impaired performance on memory tasks. In aged mice, lentiviral expression of Rbap48 in the dentate gyrus improved memory performance, whereas expression of a control gene did not. Next steps could include developing brain-permeable compounds that increase RBAP48 activity in the brain.

SciBX 6(37); doi:10.1038/scibx.2013.1033
Published online Sept. 26, 2013

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Pavlopoulos, E. et al. Sci. Transl. Med.; published online Aug. 28, 2013;
Contact: Eric R. Kandel, Columbia University, New York, N.Y.
Contact: Scott A. Small,
same affiliation as above