This week in therapeutics




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Colorectal cancer (CRC)

Fibroblast growth factor receptor 4 (FGFR4; CD334)

Cell culture and mouse studies suggest antagonizing FGFR4 could help treat colorectal cancer. In cell culture, human CRC cells cocultured with tumor-associated fibroblasts had higher levels of FGFR4 than control cultures without fibroblasts. In a mouse xenograft model of CRC, small hairpin RNA knockdown of FGFR4 decreased tumor growth and metastasis and increased survival compared with no knockdown. Next steps include identifying and testing pharmacological inhibitors of FGFR4.

SciBX 6(37); doi:10.1038/scibx.2013.1026
Published online Sept. 26, 2013

Unpatented; licensing status not applicable

Liu, R. et al. Cancer Res.;
published online Aug. 13, 2013;
Contact: Canhua Huang, Sichuan University, Chengdu, China