Thursday, September 19, 2013
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respiratory syncytial virus (RSV)
F protein; RSV
Cell culture and mouse
studies suggest the human mAb MPE8 could help treat or prevent RSV
and metapneumovirus (MPV) infection. The antibody was isolated from
immortalized memory B cells obtained from blood donors with high serum
neutralizing antibody titers against both viruses. In vitro and in
cell culture, MPE8 neutralized RSV and MPV by binding to the prefusion F
protein. In a mouse model of RSV infection, MPE8 was 5- to 10-fold more
potent than Synagis palivizumab at
decreasing virus levels in the lung. Next steps could include a clinical
trial of MPE8 in transplant patients who have an upper respiratory tract
infection caused by RSV or MPV.
AstraZeneca plc and Abbott Laboratories market
Synagis, a humanized mAb against RSV F protein, as a prophylactic for RSV
a humanized anti-RSV F protein mAb, is in Phase III trials as a prophylactic
for RSV infection.
Published online Sept. 19, 2013
Patent application filed;
available for licensing through Humabs BioMed S.A.
Corti, D. et al. Nature;
published online Aug. 18, 2013;
Contact: Antonio Lanzavecchia, University of Lugano,
Contact: Davide Corti, Humabs BioMed S.A., Bellinzona,
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