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Cardiovascular disease

Ischemia/reperfusion injury

R-Spondin 3 (RSPO3)

Mouse studies suggest RSPO3 could help treat ischemia/reperfusion injury. Ischemia/reperfusion injury causes vascular leakage that leads to tissue damage and inflammation. In a mouse model of intestinal ischemia/reperfusion injury, recombinant mouse Rspo3 decreased vascular leakage, inflammation and damage in intestinal tissue compared with no Rspo3. Next steps could include developing and testing RSPO3 mimics.

SciBX 6(36); doi:10.1038/scibx.2013.994
Published online Sept. 19, 2013

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Kannan, L. et al. Proc. Natl. Acad. Sci. USA; published online Aug. 13, 2013;
Contact: George C. Tsokos, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass.
Contact: Lakshmi Kannan, same affiliation as above