This week in therapeutics




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Endocrine/metabolic disease


Peroxisome proliferation-activated receptor-a (PPARA; PPARa)

Mouse studies suggest the gut lipid messenger oleoylethanolamine (OEA) could help prevent diet-induced obesity. In mice fed a high-fat diet, intraduodenal OEA led to intestinal Ppara activation and decreased both weight gain and fat intake compared with vehicle. In mice, OEA reversed high-fat diet-induced loss of dopaminergic signaling in the brain. Next steps include evaluating the effects of OEA supplementation on dopamine-dependent behaviors in obese subjects.

SciBX 6(35); doi:10.1038/scibx.2013.962
Published online Sept. 12, 2013

Unpatented; licensing status not applicable

Tellez, L.A. et al. Science; published online Aug. 16, 2013;
Contact: Ivan E. de Araujo, The John B. Pierce Laboratory, New Haven, Conn.