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Graft-versus-host disease (GvHD)

Protein kinase Ca (PRKCA); protein kinase Cq (PRKCQ)

Mouse studies suggest dual inhibition of PRKCA and PRKCQ could help prevent GvHD. In a mouse model of myeloablative hematopoietic cell transplantation, a dual inhibitor of PRKCA and PRKCQ decreased donor T cell proliferation, migration, chemokine and cytokine production and GvHD compared with vehicle. Next steps include testing the dual inhibitor in xenograft models of GvHD and analyzing its pharmacokinetics in primates.

SciBX 6(34); doi:10.1038/scibx.2013.936
Published online Sept. 5, 2013

Patent filed by Rigel Pharmaceuticals Inc.; available for licensing

Haarberg, K.M.K. et al. Blood; published online Aug. 1 2013;
Contact: Xue-Zhong Yu, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Fla.