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Parathyroid hormone 2 (PTH2; TIP39); PTH2 receptor (PTH2R)

Mouse studies suggest antagonizing PTH2R could help treat chronic pain. In mouse models of chronic neuropathic and inflammatory pain, knockout of the neuropeptide Pth2 or its receptor, Pth2r, decreased hypersensitivity reactions compared with no knockout. In mice, lentivirus-mediated expression of a Pth2r antagonist in the locus coeruleus of the brain decreased neuropathic pain compared with what was seen using a control vector. Next steps could include testing viral vectors that express the PTH2R antagonist in preclinical models of chronic pain.

SciBX 6(34); doi:10.1038/scibx.2013.933
Published online Sept. 5, 2013

Unpatented; a small molecule antagonist of PTH2R is available for licensing

Dimitrov, E.L. et al. Proc. Natl. Acad. Sci. USA; published online
July 22, 2013;
Contact: Ted B. Usdin, National Institute of Mental Health, Bethesda, Md.