Licensing status

Publication and contact information



Not applicable

Cell culture and mouse studies suggest inhibiting glucose transporters, glycolysis or autophagy could help eliminate senescent cancer cells. In multiple cancer cell cultures and in a mouse model of lymphoma, chemotherapy-induced senescence increased levels of glucose, glycolysis, proteotoxic stress and autophagy compared with those in cells that were not senescent. In chemotherapy-pretreated cancer cell cultures and mouse models of lymphoma, inhibitors of glucose transporters, glycolysis or autophagy decreased cell viability and tumor growth compared with no treatment. Future studies could include testing additional inhibitors of autophagy in chemotherapy-treated animal models of cancer (see Ex-SASP-erating cancer, page 5).

SciBX 6(34); doi:10.1038/scibx.2013.921
Published online Sept. 5, 2013

Unpatented; unlicensed; available for partnering

Dörr, J.R. et al. Nature;
published online Aug. 14, 2013;
Contact: Clemens A. Schmitt, Charité-University Hospital Berlin, Berlin, Germany