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Epilepsy; seizures

Microtubule-associated protein-t (MAPT; TAU; FTDP-17)

Mouse studies suggest inhibiting TAU protein could help prevent seizures. In a mouse model of severe seizures, high Tau protein levels resulted in quicker progression to severe seizures than low Tau protein levels. In mice, intracerebroventricular delivery of Tau-targeting antisense oligonucleotides (ASOs) decreased Tau protein levels and severity of pentylenetetrazole-induced seizures compared with scrambled ASOs. Next steps could include testing ASOs in epilepsy patients.

SciBX 6(33); doi:10.1038/scibx.2013.900
Published online Aug. 29, 2013

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De Vos, S.L. et al. J. Neurosci.; published online July 31, 2013;
Contact: Timothy M. Miller, Washington University in St. Louis,
St. Louis, Mo.