This week in therapeutics




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Alzheimer's disease (AD)

b-Amyloid (Ab)

In silico and in vitro studies identified Ab fiber-binding compounds that could help treat AD. In a structure-based computational screen of 18,000 compounds for Ab fiber binding, the 25 top-ranked hits were selected for experimental validation. In binding assays and human cell lines, eight hits bound Ab fibers and decreased Ab-associated cytotoxicity compared with no treatment. Next steps include evaluating the lead compounds in additional cellular and animal models of AD.

SciBX 6(33); doi:10.1038/scibx.2013.897
Published online Aug. 29, 2013

Patent application filed; licensed

Jiang, L. et al. eLife; published online July 16, 2013;
Contact: David S. Eisenberg, University of California, Los Angeles, Calif.