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Hematologic mobilization

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Mouse studies suggest the nucleotide sugar uridine diphosphate glucose (UDP-glucose) could be useful for stem cell mobilization in potential bone marrow donors. In mice, injection of UDP-glucose increased hematopoietic stem and progenitor cell mobilization from the bone marrow compared with vehicle injection. In lethally irradiated mice, donor stem cells mobilized with UDP-glucose showed better long-term engraftment and repopulation capacity than cells mobilized with G-CSF (CSF3). Next steps include studies to determine whether UDP-glucose can synergize with other stem cell mobilization compounds and whether it could be used in combination with G-CSF in a clinical trial.

SciBX 6(33); doi:10.1038/scibx.2013.893
Published online Aug. 29, 2013

Patent application filed; available for licensing from the University of Pittsburgh
Contact: Alexander P. Ducruet, University of Pittsburgh, Pittsburgh, Pa.
phone: 412-648-2219

Kook, S. et al. J. Clin. Invest.; published online July 25, 2013;
Contact: Byeong-Chel Lee, University of Pittsburgh Cancer Institute, Pittsburgh, Pa.