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Autoimmune disease

Autoimmune disease

Natural killer p30 receptor (NKp30; NCR3; CD337)

Patient studies suggest inhibiting NKp30 could help treat the autoimmune disease primary Sjögren's syndrome (pSS). In pSS, exocrine glands are destroyed by an NK-driven autoimmune reaction. In samples from patients who have pSS, the rs11575837 SNP in NKp30 was associated with lower NKp30 expression and disease risk than wild-type NKp30. In biopsies from patients who carry rs11575837, NK cells showed less NKp30-mediated interferon-g (IFNG; IFN-g) release than NK cells in biopsies from healthy individuals. Next steps include identifying the subtypes of NK cells present in exocrine glands and identifying alternative receptors for NKp30 ligands.

SciBX 6(33); doi:10.1038/scibx.2013.883
Published online Aug. 29, 2013

Unpatented; licensing status not applicable

Rusakiewicz, S. et al. Sci. Transl. Med.; published online July 24, 2013;
Contact: Gaetane Nocturne, Institut National de la Santé et de la Recherche Médicale (INSERM), Villejuif, France
Contact: Xavier Mariette, same affiliation as above