This week in therapeutics

Indication

Target/marker/pathway

Summary

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Musculoskeletal disease

Musculoskeletal disease

Transmembrane protein 8c (TMEM8C; myomaker)

In vitro and mouse studies suggest TMEM8C could enhance muscle repair. In mice, Tmem8c deletion prevented fusion of myoblasts and formation of multinucleated muscle fibers. In mice with sustained muscle injuries, Tmem8c was upregulated during muscle regeneration. In cultured muscle cells, retrovirus-mediated overexpression of Tmem8c increased myoblast fusion compared with normal expression. Next steps could include testing the effect of Tmem8c overexpression on muscle regeneration in vivo.

SciBX 6(32); doi:10.1038/scibx.2013.867
Published online Aug. 22, 2013

Patent and licensing status unavailable

Millay, D.P. et al. Nature; published online July 17, 2013;
doi:10.1038/nature12343
Contact: Eric N. Olson, The University of Texas Southwestern Medical Center, Dallas, Texas
e-mail:
eric.olson@utsouthwestern.edu