This week in therapeutics




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Publication and contact information

Endocrine/metabolic disease

Metabolic syndrome; diabetes

Stimulated by retinoic acid 6 (STRA6)

Mouse studies suggest antagonizing STRA6 could help treat metabolic syndrome and type 2 diabetes. STRA6 is a plasma membrane receptor that aids the absorption of retinol. In mice on a high-fat diet, Stra6 deletion improved glucose tolerance and insulin response without impairing retinol metabolism in peripheral tissue. Next steps include identifying Stra6-antagonizing mAbs and testing their effects in mouse models of metabolic disease.

SciBX 6(32); doi:10.1038/scibx.2013.863
Published online Aug. 22, 2013

Patent pending; available for licensing

Berry, D.C. et al. J. Biol. Chem.; published online July 9, 2013;
Contact: Norbert B. Ghyselinck, University of Strasbourg, Illkirch, France

Contact: Noa Noy, Case Western Reserve University School of Medicine, Cleveland, Ohio