Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Liver cancer

DNA

In vitro and mouse studies suggest a new class of metal hydrides could help treat cancer. In a human liver cancer cell line, a lead DNA-binding arylnitrone iridium hydride complex decreased proliferation and increased apoptosis with >20-fold higher potency than cisplatin. In mice with murine liver tumors, the lead complex decreased tumor growth with potency comparable to cisplatin without inducing weight loss or other markers of toxicity. Ongoing studies include synthesizing and testing other metal hydride complexes in human cancer cell lines.

SciBX 6(31); doi:10.1038/scibx.2013.823
Published online Aug. 15, 2013

Patented by Sinocompound Catalysts Co. Ltd.; available for licensing or partnering

Song, X., et al., J. Med. Chem.; published online July 11, 2013;
doi:10.1021/jm4004973
Contact: Jing Zhao, Nanjing University, Nanjing, China
e-mail:

jingzhao@nju.edu.cn