Licensing status

Publication and contact information


Colorectal cancer

Cystathionine b-synthase (CBS)

In vitro and mouse studies suggest inhibiting CBS could help treat colorectal cancer. In a human colon cancer cell line, small hairpin RNA−mediated knockdown of CBS or a CBS inhibitor decreased proliferation, migration and invasion compared with control shRNA or vehicle. In mice bearing human cell line−derived or patient-derived colon tumors, a CBS inhibitor decreased tumor growth and tumor blood vessel density compared with vehicle. Future studies could include determining whether CBS is overexpressed in other solid tumor types.

SciBX 6(31); doi:10.1038/scibx.2013.821
Published online Aug. 15, 2013

Patented by The University of Texas Medical Branch; licensing status undisclosed

Szabo, C. et al. Proc. Natl. Acad. Sci. USA; published online July 8, 2013;
Contact: Mark R. Hellmich, The University of Texas Medical Branch, Galveston, Texas
Contact: Csaba Szabo, same affiliation as above