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Breast cancer

Polo-like kinase 4 (PLK4; STK18)

In vitro and mouse studies identified small molecule PLK4 inhibitors that could help treat breast cancer. Computational modeling, chemical synthesis and in vitro testing of (indazolyl)methylene indolinone analogs identified several lead compounds as selective, nanomolar inhibitors of PLK4. In multiple human breast cancer cell lines, one lead compound inhibited growth at low nanomolar IC50 values. In mice with xenograft breast tumors, the lead compound decreased tumor growth compared with vehicle. Ongoing work includes IND-enabling studies of an optimized PLK4 inhibitor and planning of a Phase I trial of that inhibitor to treat solid tumors.

SciBX 6(31); doi:10.1038/scibx.2013.819
Published online Aug. 15, 2013

Patented by the University Health Network; available for licensing or partnering

Laufer, R. et al. J. Med. Chem.; published online July 6, 2013;
Contact: Henry W. Pauls, The Campbell Family Cancer Research Institute at the Princess Margaret Cancer Centre, Toronto, Ontario, Canada