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Autoimmune disease

Multiple sclerosis (MS)


Cell culture and mouse studies suggest the tocopherol derivative TFA-12 could help promote remyelination in MS. In primary cell culture, TFA-12 suppressed astroglial and microglial activation and promoted the differentiation of precursor cells into oligodendrocytes with myelin-like sheaths. In mice with experimental autoimmune encephalomyelitis or lysolecithin-induced demyelination, TFA-12 reduced demyelination and enhanced remyelination. Next steps include further evaluation of TFA-12 in models of MS and in human oligodendrocytes.

SciBX 6(31); doi:10.1038/scibx.2013.817
Published online Aug. 15, 2013

Patent application filed covering the use of TFA derivatives as inhibitors of Notch signaling; licensing status unavailable

Blanchard, B. et al. J. Neurosci.; published July 10, 2013;
Contact: Brahim Nait Oumesmar, Pierre and Marie Curie University, Paris, France