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Autoimmune disease

Inflammatory bowel disease (IBD)

Not applicable

Mouse studies identified a combination of
17 Clostridia strains (17-mix) that could help treat inflammatory bowel disease. In germ-free mice, inoculation with human fecal samples led to identification of 17 Clostridia strains that increased the population of colonic Treg cells compared with no inoculation. In a mouse model of allergic diarrhea, 17-mix reduced the occurrence and severity of diarrhea compared with vehicle. In a mouse model of colitis, 17-mix decreased colon shortening and normalized colonic histology compared with vehicle. Next steps include testing 17-mix in other preclinical models of inflammatory bowel disease.
Vedanta Biosciences Inc. has 17-mix in preclinical development to treat inflammatory bowel disease.

SciBX 6(31); doi:10.1038/scibx.2013.816
Published online Aug. 15, 2013

Patented by University of Tokyo; licensed to Vedanta Biosciences Inc.

Atarashi, K. et al. Nature; published online July 10, 2013;
Contact: Kenya Honda, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan