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Nerve damage

Scavenger receptor class B member 2 (SCARB2)

Cell culture and rat studies suggest SCARB2 could help treat nerve damage. In rat primary dorsal root ganglion (DRG) cells, Scarb2 overexpression in cocultured fibroblasts increased neurite outgrowth compared with overexpression of a control gene. In a rat model for neuronal injury, injection of Scarb2-overexpressing fibroblasts increased the number of regenerating DRG axons compared with injection of fibroblasts overexpressing a control gene. Next steps could include testing SCARB2 in additional nerve injury models.

SciBX 6(30); doi:10.1038/scibx.2013.799
Published online Aug. 8, 2013

Unpatented; licensing status not applicable

Roet, K.C.D. et al. J. Neurosci.;
published online July 3, 2013;
Contact: Kasper C.D. Roet, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands