Thursday, August 8, 2013
Publication and contact
Adenosine A2B receptor (ADORA2B)
sample and mouse studies suggest agonizing ADORA2B could help
prevent ischemia and reperfusion injury during liver transplant. In liver
biopsies obtained from patients undergoing liver transplant, ADORA2B
levels were higher after ischemia and reperfusion. In mice undergoing liver
ischemia and reperfusion, pretreatment with an ADORA2B agonist
decreased liver injury and inflammation compared with vehicle pretreatment.
Next steps include identifying alternative ADORA2B agonists for
Sciences Inc. and Astellas
Pharma Inc., market the ADORA2A
as a cardiovascular imaging agent.
Therapeutics LLC's ADORA2A
is in Phase III testing as a cardiovascular imaging agent.
Orphan Biovitrum AB's BVT.115959,
an ADORA2A agonist, is in Phase II to treat pain.
Published online Aug. 8, 2013
status not applicable
Zimmerman, M.A. et al.
Proc. Natl. Acad. Sci. USA; published online
June 28, 2013;
Contact: Holger K. Eltzschig, University of Colorado Denver,
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]