Thursday, August 8, 2013
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Adenosine A2B receptor (ADORA2B)
sample and mouse studies suggest agonizing ADORA2B could help
prevent ischemia and reperfusion injury during liver transplant. In liver
biopsies obtained from patients undergoing liver transplant, ADORA2B
levels were higher after ischemia and reperfusion. In mice undergoing liver
ischemia and reperfusion, pretreatment with an ADORA2B agonist
decreased liver injury and inflammation compared with vehicle pretreatment.
Next steps include identifying alternative ADORA2B agonists for
Sciences Inc. and Astellas
Pharma Inc., market the ADORA2A
as a cardiovascular imaging agent.
Therapeutics LLC's ADORA2A
is in Phase III testing as a cardiovascular imaging agent.
Orphan Biovitrum AB's BVT.115959,
an ADORA2A agonist, is in Phase II to treat pain.
Published online Aug. 8, 2013
status not applicable
Zimmerman, M.A. et al.
Proc. Natl. Acad. Sci. USA; published online
June 28, 2013;
Contact: Holger K. Eltzschig, University of Colorado Denver,
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