Thursday, August 8, 2013
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Adrenergic receptor b2 (ADRB2);
acetylcholine receptor M1 (CHRM1;
Mouse studies suggest
inhibiting autonomic nerve development in the tumor microenvironment could
help treat and prevent prostate cancer. In mice implanted with bioluminescent
human prostate cancer cells, surgical or pharmacological elimination of
sympathetic nerves in the prostate or knockout of ADRB2 and ADRB3
prevented tumor initiation. In the mouse model, inhibition of parasympathetic
neuron signaling by genetic knockout or pharmacological antagonism of Chrm1
decreased cell invasion and metastasis compared with no inhibition. Next
steps include assessing the safety and efficacy of adrenergic and muscarinic
inhibitors in the indication.
plc markets the ADRB2 antagonist Coreg
to treat heart failure, hypertension and myocardial infarction (MI).
Inc. and Akrimax
Pharmaceuticals LLC market the ADRB2 antagonist Inderal LA
propranolol to treat hypertension.
At least four companies market CHRM1 antagonists to treat incontinence or
Published online Aug. 8, 2013
Patent application filed;
available for licensing
Magnon, C. et al.
published online July 12, 2013;
Contact: Claire Magnon,
Albert Einstein College of Medicine of Yeshiva University, Bronx, N.Y.
Contact: Paul S. Frenette,
same affiliation as above
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