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Cancer

Cancer

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Mouse studies suggest inhibiting the formation of neutrophil extracellular traps (NETs) could help prevent cancer metastasis after surgery. Postoperative infectious complications such as sepsis have been shown to increase the risk of death from metastatic cancer. In a mouse model for surgery-induced sepsis, injection of murine lung carcinoma cells led to greater hepatic metastasis than sham-operated, nonseptic controls. In septic mice injected with the carcinoma cells, reagents that inhibited NET formation prevented the sepsis-associated increase in hepatic metastasis. Next steps could include developing inhibitors of NET formation that have drug-like properties.

SciBX 6(30); doi:10.1038/scibx.2013.785
Published online Aug. 8, 2013

Patent and licensing status unavailable

Cools-Lartigue, J. et al. J. Clin. Invest.; published online July 1, 2013;
doi:10.1172/JCI67484
Contact: Lorenzo Ferri, McGill University, Montreal, Quebec, Canada
e-mail:
lorenzo.ferri@mcgill.ca